Industrial method for removing protease during extraction process of collagen protein

The invention relates to the technical field of purification of collagen protein and particualry relates to an industrial method for removing protease during extraction process of collagen protein. The industrial method includes the following steps: 1) preparing a mixture solution of collagen protein and protease; 2) regulating pH value of the mixture solution to the isoelectric point of collagenprotein, and when the collagen protein is precipitated and separated out, filtering the mixture solution and discarding the mother liquid to obtain white precipitate, which is the collagen protein; 3)washing and filtering the collagen protein with water. The industrial method can quickly remove the protease from the collagen protein, and solves a problem of difficulty of removal of the protease in the extraction process of collagen protein. The method successfully avoid introduction of impurity ions due to salting-out of the collagen protein and increased possibility of damage on structures of the collagen protein sin