Crystallization method of cephalosporins

Belonging to the field of industrial production technologies of beta-lactam antibiotics, the invention discloses a crystallization method of cephalosporins. The method is carried out in 2-4 crystallization kettles continuously. The method has the advantages of high continuation degree, simple operat...

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Hauptverfasser: ZHANG JUNLI, LIU QIAN, CUI KEJIAO, ZHAO BIN, ZANG FEI, DUAN SUYING, WANG XINHUI, LI XIAORUI, ZHANG DEJIANG, SONG BIN, ZHANG SUOQING, GONG JUNBO, WANG MINGBO, CAO HUAN, DUAN ZHIGANG, LIN LANLAN, MU JUNMING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Belonging to the field of industrial production technologies of beta-lactam antibiotics, the invention discloses a crystallization method of cephalosporins. The method is carried out in 2-4 crystallization kettles continuously. The method has the advantages of high continuation degree, simple operation and high production efficiency, and is suitable for large-scale industrialized production, improves equipment utilization rate and product yield, and the obtained cephalosporins finished product has an ideal short rod-like crystal form, and the crystals have the characteristics of good integrity, uniform granularity, high purity, good fluidity, and convenient separation, drying and packaging. 本发明公开了种头孢类抗生素的结晶方法,属于β内酰胺类抗生素的工业化生产工艺领域,在2~4个结晶釜中连续进行;本发明具有连续化程度高、操作简单、生产效率高、适合工业化大规模生产的优点,提高了设备利用率和产品收率,得到的头孢类抗生素成品具有理想的短棒状晶型,且晶体完整度好、粒度均匀、纯度高、流动性好、便于分离、干燥和分装。