Coumarin-dithiocarbamate derivative and synthesizing method thereof

The invention discloses a coumarin-dithiocarbamate derivative and a synthesizing method thereof. The synthesizing method of the derivative comprises the following steps: 1) utilizing concentrated sulfuric acid as a catalyst, taking resorcinol and ethyl acetoacetate and putting into a first organic s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: ZHANG XIAOYING, LIANG NINGSHENG, XIE SAISAI, LEI YU, LI YAN, HUANG QICHUN, JIANG NENG, PAN WEN
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a coumarin-dithiocarbamate derivative and a synthesizing method thereof. The synthesizing method of the derivative comprises the following steps: 1) utilizing concentrated sulfuric acid as a catalyst, taking resorcinol and ethyl acetoacetate and putting into a first organic solvent to react to obtain an intermediate 2; 2) taking the intermediate 2 and dibromoalkane, puttinginto a second organic solvent and performing reaction under the condition that a pH is larger than or equal to 8 to obtain an intermediate 3; 3) taking the intermediate 3, carbon disulfide and secondary amine, putting into a third organic solvent and performing reaction under the condition that a pH is larger than or equal to 8 to obtain a corresponding target compound crude product. The synthesizing method disclosed by the invention has the advantages of simpleness and easiness in operation, high yield and stable quality; the synthesized coumarin-dithiocarbamate derivative has better acetylcholine esterase inhibitin