5'-SUBSTITUTED NUCLEOSIDE ANALOGS

The present invention relates to novel 5-substituted nucleoside compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer, in particular glioblastomas, melanoma, sarcomas, gastric cancer, pancreatic cancer, cholangiocarcinoma, bladder cancer, breast cancer, non-small cell lung cancer, leukemiasincluding acute myeloid leukemia, and lymphomas. 本发明涉及新型5'-取代的核苷化合物，包含所述化合物的药物组合物，和使用所述化合物以治疗癌症、更具体地用于治疗癌症的方法，所述癌症尤其为胶质母细胞瘤、黑色素瘤、肉瘤、胃癌、胰腺癌、胆管癌、膀胱癌、乳腺癌、非小细胞肺癌、白血病(包括急性骨髓白血病)和淋巴瘤。