Isotope substituted targeted melanoma positron imaging agent and preparation method and application of isotope substituted targeted melanoma positron imaging agent

The invention relates to the technical field of PET (Positron Emission Tomography) and particularly relates to an isotope substituted targeted melanoma positron imaging agent and a preparation methodand an application of the isotope substituted targeted melanoma positron imaging agent. The invention provides a compound shown as in the formula I, and a preparation method and an application of thecompound. The compound is rapidly combined with a melanoma cell, the binding force is strong, the sensitivity is high, the specificity is good, and tiny lung and liver metastasis can still be sensitively detected under the condition that the uptake ratio of the compound by the liver is obviously reduced. In addition, the preparation method of the imaging agent is simple, a product is easy to get,and the stability is excellent. 本发明涉及PET技术领域，具体涉及种同位素取代的靶向黑色素瘤的正电子显像剂及其制备方法与用途。本发明提供式I所示的化合物，其制备方法和用途。所述化合物与黑色素瘤细胞结合迅速，结合力强，灵敏度高，特异性佳，并且在显著降低肝脏对本发明化合物的摄取率的情况下，微小的肺和肝转移仍然可以被灵敏地探测。并且，本发明的显像剂制备方法简单、产品易得，稳定性好。