Crystal form H of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid as well as preparation method and application of crystal form H

The invention provides a novel crystal form, namely a crystal form H, of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid and further provides a preparation method of the crystal form H of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid. The crystal form H of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid, disclosed by the invention contains no crystal solvents or water, has a good crystal form and is good in stability, not easy to absorb moisture, suitable for recrystallization purification and capable of effectively removing impurities. 本发明提供种3α,7α-二羟基-6α-乙基-5β-胆烷酸的新晶型，即晶型H，本发明还提供3α,7α-二羟基-6α-乙基-5β-胆烷酸晶型H的制备方法。本发明公开的3α,7α-二羟基-6α-乙基-5β-胆烷酸晶型H，不含结晶溶剂或水，具有良好的结晶形式，且稳定性好，不易吸潮，适合重结晶纯化，可有效除去杂质。