Vilazodone intermediate synthesis method

The invention discloses a Vilazodone intermediate synthesis method. According to the Vilazodone intermediate synthesis method, 6-nitrocoumarin serves as an initial raw material, through the steps of ring opening, intramolecular cyclization, esterification, reduction, piperazine-ring preparation and the like, the key Vilazodone intermediate 5-(1-piperazinyl)-2-benzofuran-2-carboxylic acid ethyl ester shown in the formula I is obtained. The Vilazodone intermediate synthesis method is simple is synthesis path, the yield of the targeted product is high, and the Vilazodone intermediate synthesis method is suitable for industrial large-scale production. 本发明涉及种维拉佐酮中间体合成方法，以6-硝基香豆素为起始原料原料，经开环、分子内关环、酯化、还原、哌嗪环制备等步骤，得到维拉佐酮关键中间体式Ⅰ化合物5-(1-哌嗪基)-2-苯并呋喃-2-羧酸乙酯。本发明合成路线简单，目标产物收率较高，适合工业化放大生产。