HYPOESTOXIDE, DERIVATIVES, RELATED COMPOUNDS, AND AGONISTS THEREOF FOR TREATMENT OR PREVENTION OF NEURODEGENERATIVE DISEASES

New uses of hypoestoxide, its derivatives and related compounds for treatment and prevention of neurodegenerative diseases (e.g. Parkinsons disease, Alzheimers disease, Huntingtons disease) are described. More specifically, the invention relates to methods for treating various neurodegenerative diseases through administration of hypoestoxide, its derivatives and related compounds, or a combinationthereof to a subject with a neurodegenerative disease such that the symptoms of the disease are treated or at least partially alleviated. Furthermore, the present invention further provides methods of preventing the development of neurodegenerative diseases in individuals who are predisposed to developing a neurodegenerative disease over time. 本发明描述了枪刀药素氧化物(hypoestoxide)、其衍生物和相关化合物用于治疗和预防神经退行性疾病(例如，帕金森病、阿尔茨海默病、亨廷顿病)的新用途。更具体地，本发明涉及用于通过向患有神经退行性疾病的受试者施用枪刀药素氧化物、其衍生物和相关化合物或它们的组合来治疗各种神经退行性疾病，使得所述疾病的症状得到治疗或至少部分缓解的方法。此外，本发明进步提供预防在倾向于随时间发展出神经退行性疾病的个体中发展神经退行性疾病的方法。