Chitosan hemostatic material prepared through covalent cross-linking and preparation method of chitosan hemostatic material

The invention discloses a chitosan hemostatic material prepared through covalent cross-linking and a preparation method of the chitosan hemostatic material. The chitosan hemostatic material prepared through covalent cross-linking is prepared from chitosan by covalent cross-linking with a cross-linki...

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Bibliographische Detailangaben
Hauptverfasser: HUANG SHANLINGZI, HU BIHUANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a chitosan hemostatic material prepared through covalent cross-linking and a preparation method of the chitosan hemostatic material. The chitosan hemostatic material prepared through covalent cross-linking is prepared from chitosan by covalent cross-linking with a cross-linking agent, wherein the cross-linking agent is 1,4-butanediol diglycidyl ether. The preparation method of the chitosan hemostatic material prepared through covalent cross-linking comprises steps as follows: 1), an aqueous solution is prepared from chitosan; 2), the cross-linking agent is added to the aqueous solution of chitosan and is stirred and mixed uniformly, and a mixed solution is poured into a mold and dried; the cross-linking agent is 1,4-butanediol diglycidyl ether. Chitosan is cross-linked by 1,4-butanediol diglycidyl ether under an acidic condition, wherein an ethylene oxide group in 1,4-butanediol diglycidyl ether is subjected to a ring-opening reaction with hydroxyl on chitosan under the acidic conditio