Method for detecting susceptible occupational noise deaf gene and kit thereof
The invention discloses a method for detecting a susceptible occupational noise deafness gene. The method comprises the following steps of obtaining a case group and a control group in a productive noise group; collecting the peripheral blood DNA of the case group and the control group; then, perfor...
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| creator | SHEN HUANXI LUO XIAOMING ZHU BAOLI LI XIUTING HAN LEI DOU JIANRUI |
| description | The invention discloses a method for detecting a susceptible occupational noise deafness gene. The method comprises the following steps of obtaining a case group and a control group in a productive noise group; collecting the peripheral blood DNA of the case group and the control group; then, performing typing identification on three common mutation sites GSTT1, GSTM1 and GSTP1 of GST to obtain the susceptible occupational noise deafness gene, i.e., the GSTM1 deletion form. Meanwhile, the invention also discloses a kit of the susceptible occupational noise deaf gene. The kit comprises a GSTM1 amplification primer and an Albumin amplification primer. The screening is performed during the pre-job occupational health monitoring of workers; the noise susceptible workers are discovered and are prevented from working at the noise occupation posts so as to achieve the goal of precise prevention.
本发明公开了种检测易感职业性噪声聋基因的方法，包括在生产性噪声群体中获取的病例组和对照组，采集其外周血的DNA，再对GST的三个常见的突变位点GSTT1、GSTM1和GSTP1进行分型鉴定，得到易感职业性噪声聋基因即GSTM1缺失型。同时，本发 |
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本发明公开了种检测易感职业性噪声聋基因的方法，包括在生产性噪声群体中获取的病例组和对照组，采集其外周血的DNA，再对GST的三个常见的突变位点GSTT1、GSTM1和GSTP1进行分型鉴定，得到易感职业性噪声聋基因即GSTM1缺失型。同时，本发</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171215&DB=EPODOC&CC=CN&NR=107475397A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171215&DB=EPODOC&CC=CN&NR=107475397A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHEN HUANXI</creatorcontrib><creatorcontrib>LUO XIAOMING</creatorcontrib><creatorcontrib>ZHU BAOLI</creatorcontrib><creatorcontrib>LI XIUTING</creatorcontrib><creatorcontrib>HAN LEI</creatorcontrib><creatorcontrib>DOU JIANRUI</creatorcontrib><title>Method for detecting susceptible occupational noise deaf gene and kit thereof</title><description>The invention discloses a method for detecting a susceptible occupational noise deafness gene. The method comprises the following steps of obtaining a case group and a control group in a productive noise group; collecting the peripheral blood DNA of the case group and the control group; then, performing typing identification on three common mutation sites GSTT1, GSTM1 and GSTP1 of GST to obtain the susceptible occupational noise deafness gene, i.e., the GSTM1 deletion form. Meanwhile, the invention also discloses a kit of the susceptible occupational noise deaf gene. The kit comprises a GSTM1 amplification primer and an Albumin amplification primer. The screening is performed during the pre-job occupational health monitoring of workers; the noise susceptible workers are discovered and are prevented from working at the noise occupation posts so as to achieve the goal of precise prevention.
本发明公开了种检测易感职业性噪声聋基因的方法，包括在生产性噪声群体中获取的病例组和对照组，采集其外周血的DNA，再对GST的三个常见的突变位点GSTT1、GSTM1和GSTP1进行分型鉴定，得到易感职业性噪声聋基因即GSTM1缺失型。同时，本发</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNy7EKwjAURuEuDqK-w_UBBKVK6ChFcamTe7kmf9pgyA3N7fvbwQdwOst31lXXQUdx5GUiB4XVkAYqc7HIGt4RJNbOmTVI4khJQsEC2dOABOLk6BOUdMQE8dtq5TkW7H7dVPv77dU-DsjSo2S2y6R9-zwdzdlc6sZc63_MF-bZNkM</recordid><startdate>20171215</startdate><enddate>20171215</enddate><creator>SHEN HUANXI</creator><creator>LUO XIAOMING</creator><creator>ZHU BAOLI</creator><creator>LI XIUTING</creator><creator>HAN LEI</creator><creator>DOU JIANRUI</creator><scope>EVB</scope></search><sort><creationdate>20171215</creationdate><title>Method for detecting susceptible occupational noise deaf gene and kit thereof</title><author>SHEN HUANXI ; LUO XIAOMING ; ZHU BAOLI ; LI XIUTING ; HAN LEI ; DOU JIANRUI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107475397A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SHEN HUANXI</creatorcontrib><creatorcontrib>LUO XIAOMING</creatorcontrib><creatorcontrib>ZHU BAOLI</creatorcontrib><creatorcontrib>LI XIUTING</creatorcontrib><creatorcontrib>HAN LEI</creatorcontrib><creatorcontrib>DOU JIANRUI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHEN HUANXI</au><au>LUO XIAOMING</au><au>ZHU BAOLI</au><au>LI XIUTING</au><au>HAN LEI</au><au>DOU JIANRUI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for detecting susceptible occupational noise deaf gene and kit thereof</title><date>2017-12-15</date><risdate>2017</risdate><abstract>The invention discloses a method for detecting a susceptible occupational noise deafness gene. The method comprises the following steps of obtaining a case group and a control group in a productive noise group; collecting the peripheral blood DNA of the case group and the control group; then, performing typing identification on three common mutation sites GSTT1, GSTM1 and GSTP1 of GST to obtain the susceptible occupational noise deafness gene, i.e., the GSTM1 deletion form. Meanwhile, the invention also discloses a kit of the susceptible occupational noise deaf gene. The kit comprises a GSTM1 amplification primer and an Albumin amplification primer. The screening is performed during the pre-job occupational health monitoring of workers; the noise susceptible workers are discovered and are prevented from working at the noise occupation posts so as to achieve the goal of precise prevention.
本发明公开了种检测易感职业性噪声聋基因的方法，包括在生产性噪声群体中获取的病例组和对照组，采集其外周血的DNA，再对GST的三个常见的突变位点GSTT1、GSTM1和GSTP1进行分型鉴定，得到易感职业性噪声聋基因即GSTM1缺失型。同时，本发</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Method for detecting susceptible occupational noise deaf gene and kit thereof |
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