Method for detecting susceptible occupational noise deaf gene and kit thereof

The invention discloses a method for detecting a susceptible occupational noise deafness gene. The method comprises the following steps of obtaining a case group and a control group in a productive noise group; collecting the peripheral blood DNA of the case group and the control group; then, perfor...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SHEN HUANXI, LUO XIAOMING, ZHU BAOLI, LI XIUTING, HAN LEI, DOU JIANRUI
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a method for detecting a susceptible occupational noise deafness gene. The method comprises the following steps of obtaining a case group and a control group in a productive noise group; collecting the peripheral blood DNA of the case group and the control group; then, performing typing identification on three common mutation sites GSTT1, GSTM1 and GSTP1 of GST to obtain the susceptible occupational noise deafness gene, i.e., the GSTM1 deletion form. Meanwhile, the invention also discloses a kit of the susceptible occupational noise deaf gene. The kit comprises a GSTM1 amplification primer and an Albumin amplification primer. The screening is performed during the pre-job occupational health monitoring of workers; the noise susceptible workers are discovered and are prevented from working at the noise occupation posts so as to achieve the goal of precise prevention. 本发明公开了种检测易感职业性噪声聋基因的方法,包括在生产性噪声群体中获取的病例组和对照组,采集其外周血的DNA,再对GST的三个常见的突变位点GSTT1、GSTM1和GSTP1进行分型鉴定,得到易感职业性噪声聋基因即GSTM1缺失型。同时,本发