Nanometer carrier capable of carrying antitumor drug and nucleic acid drug and antitumor drug nanometer preparation

The invention relates to a nanometer carrier capable of carrying an antitumor drug and a nucleic acid drug and an antitumor drug nanometer preparation. The nanometer carrier takes hydrophilic macromolecule as a framework material, and is formed by crosslinking the hydrophilic macromolecule and a polyamine compound, and a GSH stimulate respondence cationic compound modifies the surface of the nanometer carrier. The nanometer carrier can carry the antitumor drug and the nucleic acid drug, and the further synthesized nanometer preparation has double responsiveness in tumor cells, can respectively release the nucleic acid drug and the antitumor drug, and can obviously improve the anti-tumor effect of the drugs. 本发明涉及种可共载抗肿瘤药物和核酸药物的纳米载体及抗肿瘤药物纳米制剂，所述纳米载体以亲水性高分子作为骨架材料，由亲水性高分子与多胺类化合物交联得到，其表面修饰GSH刺激响应性的阳离子化合物。该纳米载体能够共载核酸药物和抗肿瘤药物，同时进步合成的纳米制剂在肿瘤细胞内具有双响应性，能够在肿瘤细胞内分别释放核酸药物和抗肿瘤药物，可显著提高药物的抗肿瘤作用。