Method applied to sucralose production to save DMF and improve saccharose-6-ester yield

The invention relates to a method applied to sucralose production to save DMF and improve saccharose-6-ester yield. The method comprises the steps of adding base into a DMF solution containing saccharose-6-ester to neutralize PH to 6 to 8, cooling to 10 to 15 DEG C, concentrating and dewatering the solution, adding a chlorinated agent when moisture is 2000ppm, raising a temperature to 112 to 114 DEG C, and neutralizing, concentrating, decoloring and crystallizing to obtain a coarse product of the sucralose-6-ester. Compared with the prior art, theyield of an intermediate treated by the method is improved by 10%, and meanwhile, use of a DMF raw material is reduced; when the method is applied to production, only a neutralizing kettle is specially provided; the method is simple, practical and suitable for industrial production. 本发明涉及用于三氯蔗糖生产的节省DMF及提高蔗糖-6-酯产率的方法，向含蔗糖-6-酯的DMF溶液加碱中和至PH为6-8，并降温至10-15℃，将此溶液进行浓缩除水至水分为2000ppm时，加入氯化试剂，温度升高至112-114℃，经由中和、浓缩、脱色、结晶得到三氯蔗糖-6-酯的粗品。与现有技术相比，本发明处理过的中间体，提高10%收率的同时，节省了DMF原料的使用，此方法