Licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and synthesizing method thereof
The invention discloses a licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and a synthesizing method thereof. The compound is prepared from the raw materials of licochalcone A and dimethyldiguanide, and the raw materials react under absolute ethyl alcohol whic...
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| creator | JIA MINYI JU WEIHUI DING SHUNJUN LIANG CHENGYUAN PEI SHAOMENG TIAN DANNI SUN HAN |
| description | The invention discloses a licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and a synthesizing method thereof. The compound is prepared from the raw materials of licochalcone A and dimethyldiguanide, and the raw materials react under absolute ethyl alcohol which serves as a solvent to synthesize the licochalcone A and dimethyldiguanide cyclization derivative which has not been reported. The method has the advantages of high operation safety, moderate reaction condition and suitability for industrial production.
种具有抗肿瘤活性的甘草查尔酮A与二甲双胍环合衍生物及其合成方法。该类化合物以甘草查尔酮A和二甲双胍为原料，在无水乙醇作为溶剂下反应，合成了种未见报道的甘草查尔酮A与二甲双胍环合衍生物。该方法操作安全性高，反应条件温和，适于工业化生产。 |
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种具有抗肿瘤活性的甘草查尔酮A与二甲双胍环合衍生物及其合成方法。该类化合物以甘草查尔酮A和二甲双胍为原料，在无水乙醇作为溶剂下反应，合成了种未见报道的甘草查尔酮A与二甲双胍环合衍生物。该方法操作安全性高，反应条件温和，适于工业化生产。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171208&DB=EPODOC&CC=CN&NR=107445903A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171208&DB=EPODOC&CC=CN&NR=107445903A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIA MINYI</creatorcontrib><creatorcontrib>JU WEIHUI</creatorcontrib><creatorcontrib>DING SHUNJUN</creatorcontrib><creatorcontrib>LIANG CHENGYUAN</creatorcontrib><creatorcontrib>PEI SHAOMENG</creatorcontrib><creatorcontrib>TIAN DANNI</creatorcontrib><creatorcontrib>SUN HAN</creatorcontrib><title>Licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and synthesizing method thereof</title><description>The invention discloses a licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and a synthesizing method thereof. The compound is prepared from the raw materials of licochalcone A and dimethyldiguanide, and the raw materials react under absolute ethyl alcohol which serves as a solvent to synthesize the licochalcone A and dimethyldiguanide cyclization derivative which has not been reported. The method has the advantages of high operation safety, moderate reaction condition and suitability for industrial production.
种具有抗肿瘤活性的甘草查尔酮A与二甲双胍环合衍生物及其合成方法。该类化合物以甘草查尔酮A和二甲双胍为原料，在无水乙醇作为溶剂下反应，合成了种未见报道的甘草查尔酮A与二甲双胍环合衍生物。该方法操作安全性高，反应条件温和，适于工业化生产。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjE0KwjAQhbtxIeodxgMIlVbEZSmKC3HlvgzJtBmISWnGanp6o3gAV-_xfr559rqw8sqgVd4RVIBOg-Y7iYlWc_dAx5pARWV5QmHvQNPAY7IjwZPFpIewI99bDMIKUKWKJX5JIToxFHhi18EH6jWkYCDfLrNZizbQ6qeLbH063urzhnrfUOhRkSNp6us235fl7pAXVfHP5g2Fx0fW</recordid><startdate>20171208</startdate><enddate>20171208</enddate><creator>JIA MINYI</creator><creator>JU WEIHUI</creator><creator>DING SHUNJUN</creator><creator>LIANG CHENGYUAN</creator><creator>PEI SHAOMENG</creator><creator>TIAN DANNI</creator><creator>SUN HAN</creator><scope>EVB</scope></search><sort><creationdate>20171208</creationdate><title>Licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and synthesizing method thereof</title><author>JIA MINYI ; JU WEIHUI ; DING SHUNJUN ; LIANG CHENGYUAN ; PEI SHAOMENG ; TIAN DANNI ; SUN HAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107445903A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JIA MINYI</creatorcontrib><creatorcontrib>JU WEIHUI</creatorcontrib><creatorcontrib>DING SHUNJUN</creatorcontrib><creatorcontrib>LIANG CHENGYUAN</creatorcontrib><creatorcontrib>PEI SHAOMENG</creatorcontrib><creatorcontrib>TIAN DANNI</creatorcontrib><creatorcontrib>SUN HAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIA MINYI</au><au>JU WEIHUI</au><au>DING SHUNJUN</au><au>LIANG CHENGYUAN</au><au>PEI SHAOMENG</au><au>TIAN DANNI</au><au>SUN HAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and synthesizing method thereof</title><date>2017-12-08</date><risdate>2017</risdate><abstract>The invention discloses a licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and a synthesizing method thereof. The compound is prepared from the raw materials of licochalcone A and dimethyldiguanide, and the raw materials react under absolute ethyl alcohol which serves as a solvent to synthesize the licochalcone A and dimethyldiguanide cyclization derivative which has not been reported. The method has the advantages of high operation safety, moderate reaction condition and suitability for industrial production.
种具有抗肿瘤活性的甘草查尔酮A与二甲双胍环合衍生物及其合成方法。该类化合物以甘草查尔酮A和二甲双胍为原料，在无水乙醇作为溶剂下反应，合成了种未见报道的甘草查尔酮A与二甲双胍环合衍生物。该方法操作安全性高，反应条件温和，适于工业化生产。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and synthesizing method thereof |
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