Licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and synthesizing method thereof

The invention discloses a licochalcone A and dimethyldiguanide cyclization derivative with antineoplastic activity and a synthesizing method thereof. The compound is prepared from the raw materials of licochalcone A and dimethyldiguanide, and the raw materials react under absolute ethyl alcohol which serves as a solvent to synthesize the licochalcone A and dimethyldiguanide cyclization derivative which has not been reported. The method has the advantages of high operation safety, moderate reaction condition and suitability for industrial production. 种具有抗肿瘤活性的甘草查尔酮A与二甲双胍环合衍生物及其合成方法。该类化合物以甘草查尔酮A和二甲双胍为原料，在无水乙醇作为溶剂下反应，合成了种未见报道的甘草查尔酮A与二甲双胍环合衍生物。该方法操作安全性高，反应条件温和，适于工业化生产。