Cd38 inhibitors and methods of treatment

Compounds of Formula (I) and methods of treating diseases of metabolism by modulating cellular NAD+ levels through the inhibition of the CD38 enzyme, are disclosed. Formula (I). 本发明公开了式I的化合物，以及通过抑制CD38酶来调节细胞NAD+水平，从而治疗代谢疾病的方法。式I。...

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Hauptverfasser:	HENKE BRAD RICHARD, CADILLA RODOLFO, HAFFNER CURT, BECHERER J DAVID, DEATON DAVID NORMAN, SCHULTE CHRISTIE, PREUGSCHAT FRANK
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of Formula (I) and methods of treating diseases of metabolism by modulating cellular NAD+ levels through the inhibition of the CD38 enzyme, are disclosed. Formula (I). 本发明公开了式I的化合物，以及通过抑制CD38酶来调节细胞NAD+水平，从而治疗代谢疾病的方法。式I。