SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS

Disclosed are amino triazole compounds substituted by a carboxylate functional group or an bioisosteric polar functional group. Compounds having the carboxylate moiety or carboxylate bioisostere inhibit acidic mammalian chitinase. Also provided are methods of using the compounds to treat asthma reactions caused by allergens. 本发明公开了被羧酸酯官能团或生物电子等排的极性官能团取代的氨基三唑化合物。具有羧酸部分或羧酸生物电子等排体的化合物抑制酸性哺乳动物壳多糖酶。本发明还提供利用所述化合物治疗由变应原引起的哮喘反应的方法。