1,4-dihydropyridine derivatives as well as preparation method and application thereof

The invention belongs to the field of organic chemical synthesis and application and relates to 1,4-dihydropyridine derivatives as well as a preparation method and an application thereof. The preparation method of the 1,4-dihydropyridine derivatives comprises the following steps: (1) preparing an initial sample of the 1,4-dihydropyridine derivatives; (2) recrystallizing the initial sample of the 1,4-dihydropyridine derivatives in different ways to obtain three different crystalline compounds I-y, I-o and I-r, wherein the step (1) comprises the following steps: (11) forming an intermediate 2 from 2,6-dimethyl-4H-pyran-4-one 1 as an initial material as well as Meldrum's acid through an addition-elimination reaction; (12) forming an intermediate 3 from the intermediate 2 and 4-dimethylaminobenzaldehyde through a condensation reaction; (13) synthesizing the initial sample of the 1,4-dihydropyridine derivatives from the intermediate 3 and ethylamine through nucleophilic substitution. 本发明属于有机化学合成与应用领域，涉及1,4-二氢吡啶衍生物