Coumarin-carboxylic-acid shikonin ester derivatives, as well as synthetic method and application thereof

The invention belongs to the technical field of chemical pharmaceuticals, and specifically relates to shikonin ester derivatives and an application of the shikonin ester derivatives in the aspect of inhibiting tumors. Corresponding coumarin carboxylic acid and the shikonin are connected by utilizing a synthesizing means so as to obtain corresponding ester derivatives. In vitro anti-tumor activity study has proven that the coumarin-carboxylic-acid shikonin ester derivatives have very strong inhibitory activity on tumor cell strains. 本发明属于化学制药技术领域，具体涉及类紫草宁衍生物及其在肿瘤抑制方面的应用。通过合成手段将相应香豆素羧酸与紫草宁连接，获得相应酯类衍生物，体外抗肿瘤的活性研究表明，这类香豆素羧酸紫草宁衍生物对肿瘤细胞株有很强的抑制活性。