KDM4 inhibitor based on hydroxyquinoline and preparation method thereof
The invention discloses a preparation method of a KDM4 inhibitor based on hydroxyquinoline. The preparation method comprises the following steps: reacting a compound shown in a formula (I) and a compound shown in a formula (II) to obtain a compound shown in a formula (III), and then reacting to remo...
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| creator | YANG LIANG SHAO YUNPENG JIN RIFENG |
| description | The invention discloses a preparation method of a KDM4 inhibitor based on hydroxyquinoline. The preparation method comprises the following steps: reacting a compound shown in a formula (I) and a compound shown in a formula (II) to obtain a compound shown in a formula (III), and then reacting to remove methoxy groups from the compound shown in the formula (III) to obtain a compound shown in a formula (IV); and the formulas (I), (II), (III) and (IV) are all shown in the specification.
本发明公开了种基于羟基喹啉的KDM4抑制剂的制备方法，包括：将式(Ⅰ)所示的化合物与式(Ⅱ)所示的化合物反应，得到式(Ⅲ)所示的化合物，再通过式(Ⅲ)所示的化合物进行脱甲氧基反应后得到式(Ⅳ)所示的化合物；式(Ⅰ)，式(Ⅱ)，式(Ⅲ)，式(Ⅳ)。 |
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本发明公开了种基于羟基喹啉的KDM4抑制剂的制备方法，包括：将式(Ⅰ)所示的化合物与式(Ⅱ)所示的化合物反应，得到式(Ⅲ)所示的化合物，再通过式(Ⅲ)所示的化合物进行脱甲氧基反应后得到式(Ⅳ)所示的化合物；式(Ⅰ)，式(Ⅱ)，式(Ⅲ)，式(Ⅳ)。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171124&DB=EPODOC&CC=CN&NR=107382852A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171124&DB=EPODOC&CC=CN&NR=107382852A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YANG LIANG</creatorcontrib><creatorcontrib>SHAO YUNPENG</creatorcontrib><creatorcontrib>JIN RIFENG</creatorcontrib><title>KDM4 inhibitor based on hydroxyquinoline and preparation method thereof</title><description>The invention discloses a preparation method of a KDM4 inhibitor based on hydroxyquinoline. The preparation method comprises the following steps: reacting a compound shown in a formula (I) and a compound shown in a formula (II) to obtain a compound shown in a formula (III), and then reacting to remove methoxy groups from the compound shown in the formula (III) to obtain a compound shown in a formula (IV); and the formulas (I), (II), (III) and (IV) are all shown in the specification.
本发明公开了种基于羟基喹啉的KDM4抑制剂的制备方法，包括：将式(Ⅰ)所示的化合物与式(Ⅱ)所示的化合物反应，得到式(Ⅲ)所示的化合物，再通过式(Ⅲ)所示的化合物进行脱甲氧基反应后得到式(Ⅳ)所示的化合物；式(Ⅰ)，式(Ⅱ)，式(Ⅲ)，式(Ⅳ)。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD3dvE1UcjMy8hMyizJL1JISixOTVHIz1PIqEwpyq-oLCzNzMvPycxLVUjMS1EoKEotSCxKLMkEKshNLcnIT1EoyUgtSs1P42FgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hgbmxhZGFqZGjsbEqAEAZW00Gw</recordid><startdate>20171124</startdate><enddate>20171124</enddate><creator>YANG LIANG</creator><creator>SHAO YUNPENG</creator><creator>JIN RIFENG</creator><scope>EVB</scope></search><sort><creationdate>20171124</creationdate><title>KDM4 inhibitor based on hydroxyquinoline and preparation method thereof</title><author>YANG LIANG ; SHAO YUNPENG ; JIN RIFENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107382852A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>YANG LIANG</creatorcontrib><creatorcontrib>SHAO YUNPENG</creatorcontrib><creatorcontrib>JIN RIFENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YANG LIANG</au><au>SHAO YUNPENG</au><au>JIN RIFENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>KDM4 inhibitor based on hydroxyquinoline and preparation method thereof</title><date>2017-11-24</date><risdate>2017</risdate><abstract>The invention discloses a preparation method of a KDM4 inhibitor based on hydroxyquinoline. The preparation method comprises the following steps: reacting a compound shown in a formula (I) and a compound shown in a formula (II) to obtain a compound shown in a formula (III), and then reacting to remove methoxy groups from the compound shown in the formula (III) to obtain a compound shown in a formula (IV); and the formulas (I), (II), (III) and (IV) are all shown in the specification.
本发明公开了种基于羟基喹啉的KDM4抑制剂的制备方法，包括：将式(Ⅰ)所示的化合物与式(Ⅱ)所示的化合物反应，得到式(Ⅲ)所示的化合物，再通过式(Ⅲ)所示的化合物进行脱甲氧基反应后得到式(Ⅳ)所示的化合物；式(Ⅰ)，式(Ⅱ)，式(Ⅲ)，式(Ⅳ)。</abstract><oa>free_for_read</oa></addata></record> |
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| title | KDM4 inhibitor based on hydroxyquinoline and preparation method thereof |
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