KDM4 inhibitor based on hydroxyquinoline and preparation method thereof

The invention discloses a preparation method of a KDM4 inhibitor based on hydroxyquinoline. The preparation method comprises the following steps: reacting a compound shown in a formula (I) and a compound shown in a formula (II) to obtain a compound shown in a formula (III), and then reacting to remove methoxy groups from the compound shown in the formula (III) to obtain a compound shown in a formula (IV); and the formulas (I), (II), (III) and (IV) are all shown in the specification. 本发明公开了种基于羟基喹啉的KDM4抑制剂的制备方法，包括：将式(Ⅰ)所示的化合物与式(Ⅱ)所示的化合物反应，得到式(Ⅲ)所示的化合物，再通过式(Ⅲ)所示的化合物进行脱甲氧基反应后得到式(Ⅳ)所示的化合物；式(Ⅰ)，式(Ⅱ)，式(Ⅲ)，式(Ⅳ)。