Glycyrrhizin liposome immunologic adjuvant and preparation method thereof

The invention belongs to the technical field of adjuvants of veterinary vaccines, and in particular relates to a glycyrrhizin liposome immunologic adjuvant and a preparation method thereof. The liposome immunologic adjuvant mainly consists of the following raw material components: 10-50 parts of soy...

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Hauptverfasser: JI XINGYU, GUO PINGXIA, YAO FENMAO, HU YUSHENG, QIAO YUNLONG, LI GUOHUI, JIAO JINYING, WANG YANHUI, LI ZIBO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of adjuvants of veterinary vaccines, and in particular relates to a glycyrrhizin liposome immunologic adjuvant and a preparation method thereof. The liposome immunologic adjuvant mainly consists of the following raw material components: 10-50 parts of soybean lecithin, 3-17 parts of cholesterol, 1-5 parts of butylated hydroxytoluene, 0.1-3 parts of stearyl amine, 0.1-2 parts of phosphatidic acid, 0.5-2 parts of glycyrrhizin and 0.5-2 parts of muramyl-tripeptide. The liposome immunologic adjuvant provided by the invention, which has an immunological enhancing effect, is prepared by combining the glycyrrhizin, which is extracted from a traditional Chinese medicine, namely radix glycyrrhizae, and the muramyl-tripeptide which belongs to peptide adjuvants by virtue of an injection method and a freeze-thawing method; the glycyrrhizin liposome adjuvant, when applied to vaccines, is good in safety and low in side effects, and the adjuvant, which is of a double-layer membra