Recombinant ovine pegylated interferon tau, fusion protein for preparing same and preparation method of fusion protein
The invention discloses recombinant ovine pegylated interferon tau, fusion protein for preparing the same and a preparation method of the fusion protein. The fusion protein is formed by connecting sheep interferon gamma and sheep interferon tau through a flexible linker, and the recombinant sheep pe...
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| creator | XU MUZHEN SHAN XUEQIN ZHAO JUN SHEN YONGZHOU FU XIULE XU WENJUN CHENG ZHENGYANG XIA BINGBING |
| description | The invention discloses recombinant ovine pegylated interferon tau, fusion protein for preparing the same and a preparation method of the fusion protein. The fusion protein is formed by connecting sheep interferon gamma and sheep interferon tau through a flexible linker, and the recombinant sheep pegylated interferon tau can be obtained from the fusion protein and a freeze-drying protective agent through mixing and freeze-drying. The recombinant sheep pegylated interferon tau can significantly prolong the half-life of the sheep interferon, the half-life is prolonged 10 times or higher compared with that of normal sheep interferon, and the recombinant sheep pegylated interferon tau has a broad-spectrum antiviral effect and can improve immune response of sheep.
本发明公开了种重组羊长效干扰素τ及制备此长效干扰素的融合蛋白及其制备方法，所述融合蛋白由羊干扰素γ与羊干扰素τ经柔性linker连接而形成，融合蛋白与冻干保护剂混配后经冷冻干燥即可得到重组羊长效干扰素τ。所述重组羊长效干扰素τ可显著提高羊干扰素的半衰期，较普通羊干扰素的半衰期提高10倍以上，并具有广谱抗病毒作用并能提高羊自身的免疫应答。 |
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本发明公开了种重组羊长效干扰素τ及制备此长效干扰素的融合蛋白及其制备方法，所述融合蛋白由羊干扰素γ与羊干扰素τ经柔性linker连接而形成，融合蛋白与冻干保护剂混配后经冷冻干燥即可得到重组羊长效干扰素τ。所述重组羊长效干扰素τ可显著提高羊干扰素的半衰期，较普通羊干扰素的半衰期提高10倍以上，并具有广谱抗病毒作用并能提高羊自身的免疫应答。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171117&DB=EPODOC&CC=CN&NR=107353348A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171117&DB=EPODOC&CC=CN&NR=107353348A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XU MUZHEN</creatorcontrib><creatorcontrib>SHAN XUEQIN</creatorcontrib><creatorcontrib>ZHAO JUN</creatorcontrib><creatorcontrib>SHEN YONGZHOU</creatorcontrib><creatorcontrib>FU XIULE</creatorcontrib><creatorcontrib>XU WENJUN</creatorcontrib><creatorcontrib>CHENG ZHENGYANG</creatorcontrib><creatorcontrib>XIA BINGBING</creatorcontrib><title>Recombinant ovine pegylated interferon tau, fusion protein for preparing same and preparation method of fusion protein</title><description>The invention discloses recombinant ovine pegylated interferon tau, fusion protein for preparing the same and a preparation method of the fusion protein. The fusion protein is formed by connecting sheep interferon gamma and sheep interferon tau through a flexible linker, and the recombinant sheep pegylated interferon tau can be obtained from the fusion protein and a freeze-drying protective agent through mixing and freeze-drying. The recombinant sheep pegylated interferon tau can significantly prolong the half-life of the sheep interferon, the half-life is prolonged 10 times or higher compared with that of normal sheep interferon, and the recombinant sheep pegylated interferon tau has a broad-spectrum antiviral effect and can improve immune response of sheep.
本发明公开了种重组羊长效干扰素τ及制备此长效干扰素的融合蛋白及其制备方法，所述融合蛋白由羊干扰素γ与羊干扰素τ经柔性linker连接而形成，融合蛋白与冻干保护剂混配后经冷冻干燥即可得到重组羊长效干扰素τ。所述重组羊长效干扰素τ可显著提高羊干扰素的半衰期，较普通羊干扰素的半衰期提高10倍以上，并具有广谱抗病毒作用并能提高羊自身的免疫应答。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi7EKwkAQBdNYiPoPa6-gnKKtBMXKQuzDmryLB8necbcJ-PdGSGVl9YbHzDTr7yh9-3TCouR7J6CA-t2woiInimgRvZBytyLbJTdwiF7hhKyPAyNwdFJT4hbEUo0X61dtoS9fkbc_7TybWG4SFuPOsuXl_MivawRfIAUuIdAiv203B7M3Znc8mX-cD5TlRlI</recordid><startdate>20171117</startdate><enddate>20171117</enddate><creator>XU MUZHEN</creator><creator>SHAN XUEQIN</creator><creator>ZHAO JUN</creator><creator>SHEN YONGZHOU</creator><creator>FU XIULE</creator><creator>XU WENJUN</creator><creator>CHENG ZHENGYANG</creator><creator>XIA BINGBING</creator><scope>EVB</scope></search><sort><creationdate>20171117</creationdate><title>Recombinant ovine pegylated interferon tau, fusion protein for preparing same and preparation method of fusion protein</title><author>XU MUZHEN ; SHAN XUEQIN ; ZHAO JUN ; SHEN YONGZHOU ; FU XIULE ; XU WENJUN ; CHENG ZHENGYANG ; XIA BINGBING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN107353348A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>XU MUZHEN</creatorcontrib><creatorcontrib>SHAN XUEQIN</creatorcontrib><creatorcontrib>ZHAO JUN</creatorcontrib><creatorcontrib>SHEN YONGZHOU</creatorcontrib><creatorcontrib>FU XIULE</creatorcontrib><creatorcontrib>XU WENJUN</creatorcontrib><creatorcontrib>CHENG ZHENGYANG</creatorcontrib><creatorcontrib>XIA BINGBING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XU MUZHEN</au><au>SHAN XUEQIN</au><au>ZHAO JUN</au><au>SHEN YONGZHOU</au><au>FU XIULE</au><au>XU WENJUN</au><au>CHENG ZHENGYANG</au><au>XIA BINGBING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Recombinant ovine pegylated interferon tau, fusion protein for preparing same and preparation method of fusion protein</title><date>2017-11-17</date><risdate>2017</risdate><abstract>The invention discloses recombinant ovine pegylated interferon tau, fusion protein for preparing the same and a preparation method of the fusion protein. The fusion protein is formed by connecting sheep interferon gamma and sheep interferon tau through a flexible linker, and the recombinant sheep pegylated interferon tau can be obtained from the fusion protein and a freeze-drying protective agent through mixing and freeze-drying. The recombinant sheep pegylated interferon tau can significantly prolong the half-life of the sheep interferon, the half-life is prolonged 10 times or higher compared with that of normal sheep interferon, and the recombinant sheep pegylated interferon tau has a broad-spectrum antiviral effect and can improve immune response of sheep.
本发明公开了种重组羊长效干扰素τ及制备此长效干扰素的融合蛋白及其制备方法，所述融合蛋白由羊干扰素γ与羊干扰素τ经柔性linker连接而形成，融合蛋白与冻干保护剂混配后经冷冻干燥即可得到重组羊长效干扰素τ。所述重组羊长效干扰素τ可显著提高羊干扰素的半衰期，较普通羊干扰素的半衰期提高10倍以上，并具有广谱抗病毒作用并能提高羊自身的免疫应答。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Recombinant ovine pegylated interferon tau, fusion protein for preparing same and preparation method of fusion protein |
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