Recombinant ovine pegylated interferon tau, fusion protein for preparing same and preparation method of fusion protein

The invention discloses recombinant ovine pegylated interferon tau, fusion protein for preparing the same and a preparation method of the fusion protein. The fusion protein is formed by connecting sheep interferon gamma and sheep interferon tau through a flexible linker, and the recombinant sheep pegylated interferon tau can be obtained from the fusion protein and a freeze-drying protective agent through mixing and freeze-drying. The recombinant sheep pegylated interferon tau can significantly prolong the half-life of the sheep interferon, the half-life is prolonged 10 times or higher compared with that of normal sheep interferon, and the recombinant sheep pegylated interferon tau has a broad-spectrum antiviral effect and can improve immune response of sheep. 本发明公开了种重组羊长效干扰素τ及制备此长效干扰素的融合蛋白及其制备方法，所述融合蛋白由羊干扰素γ与羊干扰素τ经柔性linker连接而形成，融合蛋白与冻干保护剂混配后经冷冻干燥即可得到重组羊长效干扰素τ。所述重组羊长效干扰素τ可显著提高羊干扰素的半衰期，较普通羊干扰素的半衰期提高10倍以上，并具有广谱抗病毒作用并能提高羊自身的免疫应答。