Method for preparing 7,10-dichloro-ethoxymethyl chloride-10-deacetylbaccatin III by using microchannel reactor

The invention provides a method for preparing 7,10-dichloro-ethoxymethyl chloride-10-deacetylbaccatin III by using a microchannel reactor. According to the invention, a selective esterification reaction is carried out in the microchannel reactor with inlets and an outlet, the method comprises the following steps: S1) preparing 10-deacetylbaccatin III source liquid and chloro-carbonic acid-2,2,2-trichloro ethyl ester source liquid, S2) conveying the 10-deacetylbaccatin III source liquid and chloro-carbonic acid-2,2,2-trichloro ethyl ester source liquid into two inlets of the microchannel reactor through a transfer pump; and S3) passing two source liquid through a mixing module and a reaction module in order, performing the selective esterification reaction, controlling the temperature of the mixing module and the reaction module being 25-50 DEG C, wherein the stay time is 30-120.6 s, and flowing a reaction solution out from the outlet. The method employs the microchannel reactor for synthesis of the 7,10-dichl