Anti-hypertension active peptide Orn-Hyp-Pro, application thereof, and medicinal composition

The invention relates to an anti-hypertension active peptide Orn-Hyp-Pro, an application thereof, and a medicinal composition. The amino acid sequence of the active peptide is ornithyl-hydroxyprolyl-proline, and the active peptide has a structure represented by formula I. The angiotensin converting...

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Bibliographische Detailangaben
Hauptverfasser:	DING FENGYUN, YU LILI, WEI ZHAOHUA, GONG TING, QIAN BINGJUN, ZHANG YUNDIE, HUO JIANGHUA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLICBEVERAGES MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The invention relates to an anti-hypertension active peptide Orn-Hyp-Pro, an application thereof, and a medicinal composition. The amino acid sequence of the active peptide is ornithyl-hydroxyprolyl-proline, and the active peptide has a structure represented by formula I. The angiotensin converting enzyme (ACE) activity inhibition concentration IC50 of the active peptide is 326.72 [mu]mol/L, the blood pressure of a congenital hypertension rat which is intragastrically administrated according to a dosage of 1.0 mg/kg body weight decreases to a lowest point of 195 mmHg from 212 mmHg 2 h later, and the drug effect lasting time is 2 h. 本发明涉及种抗高血压活性肽Orn-Hyp-Pro及应用和药物组合物。所述活性肽的氨基酸序列为：鸟氨酰-羟脯氨酰-脯氨酸，具有式I所示结构。本发明活性肽的血管紧张素转换酶(ACE)活性抑制的IC为326.72μmol/L，采用1.0mg/kg体重的剂量灌胃先天性高血压大鼠2小时后血压从212mmHg下降到最低点195mmHg，持续药效时间为2小时。