Anti-hypertension active peptide Citn-Pro-Hyp, application thereof, and medicinal composition

The invention relates to an anti-hypertension active peptide Citn-Pro-Hyp, an application thereof, and a medicinal composition. The amino acid sequence of the active peptide is citrullyl-prolyl-hydroxyproline, and the active peptide has a structure represented by formula I. The angiotensin converting enzyme (ACE) activity inhibition concentration IC50 of the active peptide is 195.61 [mu]mol/L, the blood pressure of a congenital hypertension rat which is intragastrically administrated according to a dosage of 1.0 mg/kg body weight decreases to a lowest point of 195 mmHg from 227 mmHg 4 h later, and the drug effect lasting time is 1.5 h. 本发明涉及种抗高血压活性肽Citn-Pro-Hyp及应用和药物组合物。所述活性肽的氨基酸序列为：瓜氨酰-脯氨酰-羟脯氨酸，具有式I所示结构。本发明活性肽的血管紧张素转换酶(ACE)活性抑制的IC为195.61μmol/L，采用1.0mg/kg体重的剂量灌胃先天性高血压大鼠4小时后血压从227mmHg下降到最低点195mmHg，持续药效时间为1.5小时。式I。