Anti-hypertension active peptide The-The-Pro, application thereof, and medicinal composition

The invention relates to an anti-hypertension active peptide The-The-Pro, an application thereof, and a medicinal composition. The amino acid sequence of the active peptide is theanyl-theanyl-proline, and the active peptide has a structure represented by formula I. The angiotensin converting enzyme (ACE) activity inhibition concentration IC50 of the active peptide is 0.92 [mu]mol/L, the blood pressure of a congenital hypertension rat which is intragastrically administrated according to a dosage of 1.5 mg/kg body weight decreases to a lowest point of 152 mmHg from 187 mmHg 2.5 h later, and the drug effect lasting time is 3.5 h. 本发明涉及种抗高血压活性肽The-The-Pro及应用和药物组合物。所述活性肽的氨基酸序列为：茶氨酰-茶氨酰-脯氨酸，具有式I所示结构。本发明活性肽的血管紧张素转换酶(ACE)活性抑制的IC为0.92μmol/L，采用1.5mg/kg体重的剂量灌胃先天性高血压大鼠2.5小时后血压从187mmHg下降到最低点152mmHg，持续药效时间为3.5小时。