Determination method of carbomer content in gel containing carbomer
The invention relates to a determination method of carbomer content in gel containing carbomer. The determination method is characterized by comprising the following steps: adding a certain amount of an alkaline solution to enable a carboxylic acid group of the carbomer in the gel to exist at an ion...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention relates to a determination method of carbomer content in gel containing carbomer. The determination method is characterized by comprising the following steps: adding a certain amount of an alkaline solution to enable a carboxylic acid group of the carbomer in the gel to exist at an ion state; then adding an excessive amount of a metal salt solution and sufficiently mixing metal salt and the carboxylic acid group in the carbomer to generate a complex; after removing the complex, titrating unbound metal salt by utilizing an EDTA (Ethylene Diamine Tetraacetic Acid) titrating solution, so as to calculate the content of the carbomer in a sample. The method provided by the invention is applicable to detection of the carbomer content in the gel which takes the carbomer as a gel matrix or a main component; the method is simple and accurate and has strong specificity.
本发明涉及种含有卡波姆的凝胶剂中卡波姆含量的检测方法,其特征在于,加入定量的碱溶液,使凝胶中卡波姆的羧酸基以离子状态存在,然后加入过量的金属盐溶液,使金属盐与卡波姆中的羧酸基充分结合,生成络合物,除去络合物后,再用EDTA滴定液滴定未结合的金属盐,从而计算得到样品中卡波姆的含 |
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