Application of BK channel protein in preparation of drug for intervening osteoblast cell proliferation abnormality
The invention belongs to the field of bio-pharmaceuticals, relates to an application of a BK channel protein in preparation of an osteoblast cell intervention drug, and in particular relates to an application of the BK channel protein in preparation of a drug for intervening osteoblast cell prolifer...
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| creator | HEI HONGYA TIAN LULU WANG LI ZHANG XUEMEI PENG WEN TAO JIE |
| description | The invention belongs to the field of bio-pharmaceuticals, relates to an application of a BK channel protein in preparation of an osteoblast cell intervention drug, and in particular relates to an application of the BK channel protein in preparation of a drug for intervening osteoblast cell proliferation and differentiation abnormality. According to the application disclosed by the invention, a large-conductance calcium-activated potassium channel (also called a BK channel) knockout and osteoblastic phenotype and osteoblast function decrease relationship model is established, and pathological states of osteoblast cells and functions of osteoblast cells in bone related diseases are simulated. Experimental results show that proliferation and mineralization are obviously decreased after BK knockout cloning, and general presentation of osteoblast differentiation marker genes is obviously lower than that of wild-type osteoblast. The result shows that the BK channel is an important target for regulating osteoblast |
| format | Patent |
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According to the application disclosed by the invention, a large-conductance calcium-activated potassium channel (also called a BK channel) knockout and osteoblastic phenotype and osteoblast function decrease relationship model is established, and pathological states of osteoblast cells and functions of osteoblast cells in bone related diseases are simulated. Experimental results show that proliferation and mineralization are obviously decreased after BK knockout cloning, and general presentation of osteoblast differentiation marker genes is obviously lower than that of wild-type osteoblast. 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According to the application disclosed by the invention, a large-conductance calcium-activated potassium channel (also called a BK channel) knockout and osteoblastic phenotype and osteoblast function decrease relationship model is established, and pathological states of osteoblast cells and functions of osteoblast cells in bone related diseases are simulated. Experimental results show that proliferation and mineralization are obviously decreased after BK knockout cloning, and general presentation of osteoblast differentiation marker genes is obviously lower than that of wild-type osteoblast. The result shows that the BK channel is an important target for regulating osteoblast</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | Application of BK channel protein in preparation of drug for intervening osteoblast cell proliferation abnormality |
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