Production technology for riboflavin sodium phosphate
The invention relates to a production technology for riboflavin sodium phosphate. The invention aims to realize simple technology, easy control and high yield. The production technology comprises the following steps: performing phosphorylation reaction: adding phosphorus oxychloride and acetonitrile...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention relates to a production technology for riboflavin sodium phosphate. The invention aims to realize simple technology, easy control and high yield. The production technology comprises the following steps: performing phosphorylation reaction: adding phosphorus oxychloride and acetonitrile in turn, dropwise adding pyridine of which the weight is 2/3 of the total weight, slowly dropwise adding a solution prepared from the residual pyridine and purified water and reacting for 30-60 minutes; adding vitamin B2 for performing phosphorylation reaction for 20-40 minutes under the temperature at 30-37 DEG C; while crystallizing, adding riboflavin cyclophosphate seed crystal of which the weight is 0.25-0.5% of the weight of the vitamin B2 for promoting the crystallization; performing hydrolysis reaction: adding 18%-20% hydrochloric acid solution into the separated riboflavin cyclophosphate crystal and performing hydrolysis reaction for 1-3 hours under the temperature at 45-55 DEG C; adding sodium hydroxide f |
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