4-(aromatic heterocyclic substituted)amino-1H-3-pyrazolecarboxamide FLT3 (Fms-like tyrosine kinase) inhibitor and application thereof

The invention relates to a novel 4-(aromatic heterocyclic substituted)amino-1H-3-pyrazolecarboxamide compound or pharmaceutically acceptable salts, solvates, isomers, esters, acids, metabolites or pro-drugs thereof and a preparation method thereof. The invention provides medical compositions comprising the compounds and medical application thereof. 本发明涉及种新型4-(芳杂环取代)氨基-1H-3-吡唑甲酰胺类化合物或其药学可接受的盐、溶剂化物、异构体、酯、酸、代谢物或前药，他们的制备方法，包括含此类化合物的药用组合物、以及它们的医疗用途。