Darunavir methanol solvate, and preparation method and application thereof

The invention relates to the technical field of medicine, particularly a darunavir methanol solvate, and a preparation method and application thereof. The darunavir methanol solvate has characteristic peaks when the diffraction angle 2theta is 6.9+/-0.2, 9.2+/-0.2, 11.2+/-0.2, 13.7+/-0.2, 16.6+/-0.2, 18.9+/-0.2, 20.6+/-0.2, 21.1+/-0.2 and 22.6+/-0.2. The amorphous darunavir prepared by using the darunavir methanol solvate has very high stability and HPLC purity. 本发明涉及医药技术领域，具体涉及种地瑞那韦甲醇溶剂化物及其制备方法和用途。所述的地瑞那韦甲醇溶剂化物在衍射角2θ为6.9±0.2，9.2±0.2，11.2±0.2，13.7±0.2，16.6±0.2，18.9±0.2，20.6±0.2，21.1±0.2，22.6±0.2处有特征峰。利用该地瑞那韦甲醇溶剂化物制备得到的无定型地瑞那韦具有很高的稳定性和HPLC纯度。