Reagents, methods and kits for diagnosing primary immunodeficiencies

This invention relates to the field of primary immunodeficiencies (PID), more specifically to means and method for the diagnosis of PID of the lymphoid system. Provided are unique reagent compositions for the flow cytometric immunophenotyping of leukocytes comprising fluorochrome-conjugated antibodi...

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Hauptverfasser: KALINA TOMAS, LOPEZ-GRANADOS EDUARDO, PEREZ-ANDRES MARTIN, VLKOVA MARCELA, BLANCO ALVAREZ ELENA, KIENZLER ANNE-KATHRIN, VAN DONGEN JACOBUS JOHANNES MARIA, VAN DER BURG MIRJAM, ORFAO DE MATOS CORREIA E VALE JOSE ALBERTO, VAN ZELM MENNO CORNELIS
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:This invention relates to the field of primary immunodeficiencies (PID), more specifically to means and method for the diagnosis of PID of the lymphoid system. Provided are unique reagent compositions for the flow cytometric immunophenotyping of leukocytes comprising fluorochrome-conjugated antibodies directed against various specific combinations of markers. Also provided are kits comprising the reagent compositions, and methods using the same. 本发明涉及原发性免疫缺陷(PID)领域,更具体地涉及用于诊断淋巴系统的PID的手段和方法。提供用于白细胞的流式细胞术免疫分型的独特试剂组合物,其包含针对各种特异性标记物组合的荧光染料偶联的抗体。还提供包含试剂组合物的试剂盒和使用该试剂组合物的方法。