Preparation method of ibuprofen sustained-release capsules

The invention relates to a preparation method of ibuprofen sustained-release capsules and belongs to the field of medicine preparations. The method comprises the following steps: (1) adding a mesoporous material and polyethylene glycol into a solvent, and carrying out ultrasonic treatment; and (2) a...

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Hauptverfasser: LAI MUSHUI, LAI HAIJIE
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to a preparation method of ibuprofen sustained-release capsules and belongs to the field of medicine preparations. The method comprises the following steps: (1) adding a mesoporous material and polyethylene glycol into a solvent, and carrying out ultrasonic treatment; and (2) adding ibuprofen into a solvent system, stirring and volatilizing the solvent to obtain ibuprofen-loaded mesoporous particles, coating the mesoporous particles by using an organic macromolecule auxiliary material, crushing and sieving the obtained particles, and filling capsules with the particles to obtain the ibuprofen sustained-release capsules. 本发明涉及布洛芬缓释胶囊的制备方法,属于药物制剂领域。其包括以下步骤:1)将介孔材料和聚乙二醇加入溶剂中进行超声;2)向溶剂体系中加入布洛芬,搅拌挥发溶剂获得负载布洛芬的介孔颗粒;采用有机高分子辅料对介孔颗粒进行包覆,获得的颗粒粉碎过筛,装胶囊即得。