Novel glycopeptide antibiotic derivative, pharmaceutical composition, and preparation method and application of pharmaceutical composition

The invention discloses a novel glycopeptide antibiotic derivative shown as in general formula (I) that is shown in the description, its pharmaceutically acceptable salts and a preparation method of the salts, wherein R1 is substituted or non-substituted benzene ring and diphenyl ring, a substituent of the substituted benzene ring and diphenyl ring is an alkoxy group, nitro group or isopropyl group with single or multiple halogens, hydroxy radicals, amino groups and C1-C9, and R2 is H. In addition, the invention also provides a pharmaceutical composition containing the glycopeptide antibiotic derivative and its pharmaceutically acceptable salts as active ingredients, and application of the pharmaceutical composition. The compound and pharmaceutical composition provided herein have good antibacterial activity and are significant to the development of novel antibacterial drugs. 本发明公开了类如通式(I)所示的糖肽类抗生素衍生物及其药学可接受的盐及其制备方法，其中R为为取代或未取代的苯环、联苯环，所述取代的苯环、联苯环的取代基为带有个或多个的卤素、羟基、氨基、C～C的烷氧基、硝基、或异丙基；R是H。此外，本发明还提供了含有所述糖肽类抗生素衍生物