Method for preparing metoprolol succinate sustained-release pellet tablets
The invention belongs to the technical field of medicine and relates to a method for preparing metoprolol succinate sustained-release pellet tablets. The method includes steps: dissolving metoprolol salt and a bonding agent into an appropriate solvent to prepare coating solution for a medicine layer...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention belongs to the technical field of medicine and relates to a method for preparing metoprolol succinate sustained-release pellet tablets. The method includes steps: dissolving metoprolol salt and a bonding agent into an appropriate solvent to prepare coating solution for a medicine layer; dissolving a sustained-release coating material, a plasticizer and a pore forming agent of a sustained-release compression-resistant layer into coating solution solvent to prepare coating solution for the sustained-release layer; adding appropriate auxiliary materials, well mixing, tabletting and coating. The metoprolol succinate sustained-release pellet tablets keep active component release speed unchanged even being split for administration, and active components can be continuously and slowly released within 24 hours.
本发明涉及种琥珀酸美托洛尔缓释微丸压片的制备方法,属于医药技术领域。将美托洛尔盐和粘合剂溶于适宜的溶剂中,制备药物层包衣液,再将缓释抗压层缓释包衣材料、增塑剂、致孔剂溶于包衣液溶剂中,制备缓释层包衣液,加入适当辅料混匀、压片、包衣。本发明产品具有可掰开服用依然保持活性成分释放速度不变的优点,并可在24小时内持续缓慢释放。 |
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