Method for preparing metoprolol succinate sustained-release pellet tablets

The invention belongs to the technical field of medicine and relates to a method for preparing metoprolol succinate sustained-release pellet tablets. The method includes steps: dissolving metoprolol salt and a bonding agent into an appropriate solvent to prepare coating solution for a medicine layer...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: RUAN BIFANG, LI PIN, ZHANG SHUXIANG, TENG LIJIA, JI GUOMING
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention belongs to the technical field of medicine and relates to a method for preparing metoprolol succinate sustained-release pellet tablets. The method includes steps: dissolving metoprolol salt and a bonding agent into an appropriate solvent to prepare coating solution for a medicine layer; dissolving a sustained-release coating material, a plasticizer and a pore forming agent of a sustained-release compression-resistant layer into coating solution solvent to prepare coating solution for the sustained-release layer; adding appropriate auxiliary materials, well mixing, tabletting and coating. The metoprolol succinate sustained-release pellet tablets keep active component release speed unchanged even being split for administration, and active components can be continuously and slowly released within 24 hours. 本发明涉及种琥珀酸美托洛尔缓释微丸压片的制备方法,属于医药技术领域。将美托洛尔盐和粘合剂溶于适宜的溶剂中,制备药物层包衣液,再将缓释抗压层缓释包衣材料、增塑剂、致孔剂溶于包衣液溶剂中,制备缓释层包衣液,加入适当辅料混匀、压片、包衣。本发明产品具有可掰开服用依然保持活性成分释放速度不变的优点,并可在24小时内持续缓慢释放。