6-bromotryptamine derivative as well as preparation method and application thereof

The invention discloses a 6-bromotryptamine derivative as well as a preparation method and application thereof. The 6-bromotryptamine derivative is characterized by being expressed by a structural formula (I) and comprising 6-bromotryptamine chloro-phenylacetic acid and 6-bromotryptamine phenylpropi...

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Bibliographische Detailangaben
Hauptverfasser: CUI WEI, WANG MINJUN, HUANG CHUNHUI, HE SHAN, ZHAO JIAYING, DING LIJIAN, SHENTU JIEYI, SLAVA S.EPSTEIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a 6-bromotryptamine derivative as well as a preparation method and application thereof. The 6-bromotryptamine derivative is characterized by being expressed by a structural formula (I) and comprising 6-bromotryptamine chloro-phenylacetic acid and 6-bromotryptamine phenylpropionic acid. The preparation method comprises the following steps: weighing chloro-phenylacetic acid or phenylpropionic aci, dissolving with dichloromethane, further adding EDC.HCl till a white muddy liquid is generated, further adding HOBt, stirring for 30 minutes at normal temperature till a white muddy phenomenon is vanished, detecting the reaction process through thin-layer chromatography, when new points occur, dropping dichloromethane in which 6-bromotryptamine is dissolved into a reaction liquid, performing stirring reaction at room temperature, leaving to stand over night, performing thin-layer chromatography detection, terminating reaction if raw material points are eliminated, boiling off a solvent so as to