Use of 5-methoxytryptophan as diagnostic agent of inflammatory diseases

ABSTRACT The present invention relates a diagnostic method for inflammatory diseases, and the diagnostic kit used in the method. The diagnostic method of present invention comprises the use of a novel tryptophan metabolite, 5-methoxytryptophan (5-MTP), as a diagnostic biomarker of inflammation. The...

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Hauptverfasser: KUO CHENGIN, WU KENNETH KUN-YU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:ABSTRACT The present invention relates a diagnostic method for inflammatory diseases, and the diagnostic kit used in the method. The diagnostic method of present invention comprises the use of a novel tryptophan metabolite, 5-methoxytryptophan (5-MTP), as a diagnostic biomarker of inflammation. The present invention specially provides a highly specific competitive ELISA to measure 5-MTP level in human serum for gauging occurrence and severity of inflammatory diseases, including sepsis and systemic lupus. 本发明关于种发炎疾病的诊断方法,及用于该方法的诊断套组。本发明的诊断方法包含使用种新颖色胺酸代谢物,5-甲氧基色胺酸(5-methoxytryptophan,5-MTP),作为炎症反应的诊断标记物。本发明特别提供种高度特异性竞争式免疫酵素法,借由测量人类血清中5-MTP浓度以诊断包括败血病及全身性红斑性狼疮等发炎疾病的发生与严重程度。