Agrochemical delivery system based on enzyme- or ph- responsive amphiphilic peg-dendron hybrids

The present invention relates to an amphiphilic hybrid delivery system in micellar form for delivery of agrochemicals, based on a hydrophilic polyethylene glycol (PEG) polymer conjugated to a hydrophobic dendron, the dendron comprising at least one pH-dependent or enzymatically cleavable hydrophobic end group that is covalently attached to the dendron, wherein the micelle disassembles upon enzymatic or pH-dependent cleavage of the hydrophobic end group. The hydrophobic end group that is conjugated to the dendron may comprise an agrochemical, and/or the micelle may (non-covalently) encapsulate an agrochemical. The present invention further provides methods of use thereof and to a kit comprising same. 本发明涉及基于缀合至疏水性树枝化基元的亲水性聚乙二醇(PEG)聚合物的、用于递送农用化学品的、呈胶束形式的两亲性杂化递送系统，所述树枝化基元包含共价地附接至该树枝化基元的至少个pH-依赖性的或酶可裂解的疏水性末端基团，其中胶束在疏水性末端基团的酶裂解或pH-依赖性裂解时分解。缀合至树枝化基元的疏水性末端基团可以包括农用化学品，和/或胶束可以(非共价地)封装农用化学品。本发明还提供了其使用方法和包含其的试剂盒。