3-cycloalkyl-prop-2-enamide derivatives
The invention relates to new 3-cycloalkyl-2-propenamide derivatives of formula (I): in which R1 represents H or (C1-C3)alkyl, W represents O or optionally oxidised S, Y and Z represent -CH- or one of Y and Z represents -CH and the other represents N, R2, R3, R4, R5 and R6 represent H, haloge...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | The invention relates to new 3-cycloalkyl-2-propenamide derivatives of formula (I):
in which
R1 represents H or (C1-C3)alkyl,
W represents O or optionally oxidised S,
Y and Z represent -CH- or one of Y and Z represents -CH and the other represents N,
R2, R3, R4, R5 and R6 represent H, halogen, (C1-C4)alkyl, - OCH3, -SCH3, -WCF3, NO2, CN, -W(CH2)n-CF3, -W(CF2)n-CF3 , -(CH2)n-CX3 or -(CF2)n-CF3, in which n is 1, 2 or 3 and X represents halogen or R3 and R4 together form -O-CH2-O-,
R7 and R8 represent H or (C1-C6)alkyl,
R9 represents (C3-C6)cycloalkyl,
to their tautomeric forms and to their addition salts with bases, as well as to their process of preparation, to their application as medicaments and to the compositions which contain them. |
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