NPC (nasopharyngeal carcinoma) related tumor marker and application
The invention discloses an NPC (nasopharyngeal carcinoma) related tumor marker and an application. The tumor marker is lncRNA, is positioned at the 17th chromosome chr17:47785696-47797422 and has the nucleotide sequence shown in SEQ ID NO.1 and named as lncRNA-KAT7. According to the sequence lncRNA-...
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Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses an NPC (nasopharyngeal carcinoma) related tumor marker and an application. The tumor marker is lncRNA, is positioned at the 17th chromosome chr17:47785696-47797422 and has the nucleotide sequence shown in SEQ ID NO.1 and named as lncRNA-KAT7. According to the sequence lncRNA-KAT7, the specific real-time fluorescent quantitative PCR primer is designed and synthesized, and a preparation used for NPC diagnosis or curative effect prediction is prepared. Detection of the expression level of lncRNA-KAT7 in an NPC clinical case specimen by use of the real-time fluorescent quantitative PCR preparation proves that expression of lncRNA-KAT7 in NPC is remarkably reduced, and lncRNA-KAT7 can be used for preparing a preparation or a kit for auxiliary diagnosis, curative effect prediction and prognosis of NPC.
本发明公开了种鼻咽癌相关的肿瘤标志物及应用,所述肿瘤标志物为lncRNA,定位于第17号染色体chr17:47785696-47797422,该lncRNA的核酸序列如SEQ ID NO.1所示,命名为lncRNA-KAT7。根据lncRNA-KAT7序列,设计并合成特异性实时荧光定量PCR引物,制备用于鼻咽癌诊断或者疗效预测的制剂。利用实时荧光定量PCR制剂,在鼻咽癌临床病例标本 |
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