Method for improving stability of urokinase

The invention discloses a method for improving the stability of urokinase. According to the technical scheme, heparin is adopted for chemical modification of urokinase, the water resistance of urokinase is improved, and the thermal stability and PH stability of the urokinase are high. The half-life...

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Hauptverfasser:	LIU NAISHAN, WANG QING, CHEN EGONG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMES ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a method for improving the stability of urokinase. According to the technical scheme, heparin is adopted for chemical modification of urokinase, the water resistance of urokinase is improved, and the thermal stability and PH stability of the urokinase are high. The half-life period of heparin-modified urokinase is prolonged remarkably, and the clinical application value of heparin-modified urokinase is high. 本发明公开了种提高尿激酶稳定性的方法，技术方案是采用肝素对尿激酶进行化学修饰，提高其抗水能力并使其对热和PH都有较好的稳定性。经肝素修饰后的尿激酶半衰期明显延长，有较好的临床应用价值。