Application of diphenyl ketone compounds in pharmacy

The invention discloses a novel medical application of two diphenyl ketone compounds 4,5,2'-trihydroxyl-2,5'-dibromo diphenyl ketone and 4,5,2'-tri(4-morpholine methanoyl)-2,5'-dichloro diphenyl ketone, and in particular discloses an application in preparing drugs for treating acute pyelonephritis and chronic nephritis. Meanwhile, the invention also discloses a drug, taking the two compounds as active ingredients, for treating acute pyelonephritis and chronic nephritis. Both the two compounds can effectively improve the renal functions of an acute pyelonephritis model mouse and a chronic nephritis model mouse, remarkably inhibit IL-1alpha, IL-1beta and IL-6 and reduce the inflammatory reactions, thereby showing an important application prospect in treating acute pyelonephritis and chronic nephritis. 本发明公开了两种二苯甲酮类化合物4,5,2'-三羟基-2,5'-二溴二苯甲酮和4,5,2'-三(4-吗啉甲酰氧基)-2,5'-二氯二苯甲酮的医药新用途，具体为在制备治疗急性肾盂肾炎和慢性肾炎药物中的应用，同时本发明也公开了以上述两种化合物为活性成分的治疗急性肾盂肾炎和慢性肾炎的药物。这两种化合物均能有效改善急性肾盂肾炎模型大鼠和慢性肾炎模型大鼠的肾功能，显著抑制IL-1α、IL-1β及IL-6，降低炎症反应，显示了在治疗急