Cancer diagnosis and therapy

The present invention provides a novel approach to cancer diagnosis and therapy of cancer by providing compositions and methods for the identification and specific targeting of the cancer stem cell populations present in a tumour to eradicate, or slow or prevent tumour (5) growth and spread, including the potential for tumour metastasis, by modulation of the Renin-Angiotensin System including, but not limited to, Renin Receptor, Angiotensin II Receptor (2) and a secreted form of the Renin Receptor. 本发明通过提供用于鉴定并特异性靶向存在于肿瘤中的癌症干细胞群体来消除或减慢或阻止肿瘤(5)生长和扩散(包括肿瘤转移潜能)的组合物和方法，通过调节包括但不限于肾素受体、血管紧张肽II受体(2)和肾素受体的分泌形式的肾素-血管紧张肽系统，来提供用于癌症诊断和癌症治疗的新方法。