Revaprazan hydrochloride hydrate crystal form, and preparation method and application thereof

The invention provides a revaprazan hydrochloride hydrate crystal form, and provides a preparation method, a pharmaceutical composition and application of the revaprazan hydrochloride hydrate crystal form. Revaprazan hydrochloride hydrate, provided by the invention is stable in form, and high in crystal form purity, and has a higher bioavailability and better storage stability in comparison with an evaprazan hydrochloride anhydride crystal form. The preparation method of revaprazan hydrochloride hydrate is simple to operate, the reaction condition is mild and easy to control, the production cost is low, a obtained target product is definite in crystal form and good in reproducibility. 本发明提供种瑞普拉生水合物晶型，并提供其制备方法、其药物组合物和用途。本发明所述瑞普拉生水合物形态稳定，晶型纯度高，相对于瑞普拉生无水合物晶型，其具有更高的生物利用度以及更好的贮存稳定性；本发明所述瑞普拉生水合物的制备方法操作简单，反应条件温和，容易控制，生产成本低廉，获得目标产物晶型确定且重现性好。