Preparation method of beta-carbonyl thioether

The invention discloses a preparation method of beta-carbonyl thioether. The preparation method comprises the following steps: by taking aromatic ring substituted propargyl alcohol and mercaptan as raw materials, carrying out series Meyer-Schuster rearrangement reaction and 1,4-addition reaction under the action of acid, so that one-pot process synthesis of the beta-carbonyl thioether is realized. The preparation method disclosed by the invention has the highest yield reaching 99% and has the advantages of simple operation and 100% atom economy, and a brand-new synthesis method is provided for construction of the beta-carbonyl thioether compound. 本发明公开了种β-羰基硫醚的制备方法。该制备方法以芳环取代的丙炔醇和硫醇为原料，在酸作用下进行串联的Meyer-Schuster重排反应和1,4-加成反应，从而实现β-羰基硫醚的锅法合成。本发明的制备方法最高产率可达99％，具有操作简单和100％原子经济等优点，为β-羰基硫醚类化合物的构建提供了种全新的合成方法。