Method for preparing 4,4'-diaminodiphenylmethane derivative by using microreactor

The invention discloses a method for preparing 4,4'-diaminodiphenylmethane derivative by using a microreactor. The method comprises the following steps: conveying water, a reaction solution of an inorganic acid and a formaldehyde solution into two inlets of the microreactor through a constant-f...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LI XIANMING, YANG RONGQIANG, CHEN HUAKUI, FENG BO, TONG DEBING, LI ZIJIAN, DING WEI
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a method for preparing 4,4'-diaminodiphenylmethane derivative by using a microreactor. The method comprises the following steps: conveying water, a reaction solution of an inorganic acid and a formaldehyde solution into two inlets of the microreactor through a constant-flux pump respectively, contacting, mixing and reacting in the microreactor, then cooling, dropwise adding a sodium hydroxide water solution, separating out a white precipitate, filtering, drying to obtain a 4,4'-diaminodiphenylmethane derivative (MDA, MDT or MOCA) crude product, and carrying out ethyl alcohol recrystallization, filtering and drying to obtain a pure product. According to the method, continuous preparation of the 4,4'-diaminodiphenylmethane derivative is realized by adopting the microreactor technology, and the derivative is easy for large-scale production; and the reaction speed is high, so that the reaction time is greatly shortened. 本发明公开了利用微反应器制备4,4'-二氨基二苯甲烷衍生物的方法,水、无机酸的反应液和甲醛溶液分别经由平流泵输送至微反应器的两个进口中,在微