Preparation method of bacteriostatic hydrogel for wound healing

The invention discloses a preparation method of a bacteriostatic hydrogel for wound healing. The preparation method comprises the following steps of (1) dispersing locust bean gum into deionized water, adding sodium periodate for stirring reaction at 40-60 DEG C for 4-8h, transferring a reaction liq...

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1. Verfasser: QIU FALONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of a bacteriostatic hydrogel for wound healing. The preparation method comprises the following steps of (1) dispersing locust bean gum into deionized water, adding sodium periodate for stirring reaction at 40-60 DEG C for 4-8h, transferring a reaction liquid into a dialysis bag having molecular weight cut off of 6,000 for dialysis to obtain oxidized locust bean gum, wherein the oxidation degree of the oxidized locust bean gum is 25-40%; and (2) adding the oxidized locust bean gum obtained in the step (1) and poly allylamine to a calcium chloride water solution, carrying out ultrasonic treatment for 10-30min and standing to obtain the hydrogel for promoting wound healing. The hydrogel prepared by the preparation method has good antibacterial activity and good biocompatibility, and is safe and free of irritation to a skin wound. Meanwhile, the hydrogel is capable of fully absorbing exudates of the wound, and swelling to maintain the wound physiologically moist after