PH-sensitive self-repairing hydrogel and preparation method of same
The invention discloses a pH-sensitive self-repairing hydrogel and a preparation method of same. The hydrogel is produced by crosslinking dopamine-modified sodium alginate and sodium carboxymethylcellulose modified by 3-aminophenylboronic acid according to a certain ratio, wherein the modified sodiu...
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| creator | CUI GUOLIAN YOU WEITING DAN WEIHUA DAN NIANHUA |
| description | The invention discloses a pH-sensitive self-repairing hydrogel and a preparation method of same. The hydrogel is produced by crosslinking dopamine-modified sodium alginate and sodium carboxymethylcellulose modified by 3-aminophenylboronic acid according to a certain ratio, wherein the modified sodium alginate and sodium carboxymethylcellulose respectively have a catechol group and a phenylboronic acid group, so that between the two groups, a pH-sensitive phenylborate bond can be formed. The phenylborate bond is fractured if pH < 7 and is recovered if pH > 7, so that the hydrogel has a pH-responded self-repairing performance. A main raw material of the hydrogel is natural polysaccharide, so that the hydrogel has excellent biocompatibility and also has pH-responding property and self-repairing performance. The hydrogel has wide applications in the fields of controllable release of drugs, tissue engineering and the like.
本发明公开了种pH敏感自修复水凝胶及其制备方法。所述水凝胶由多巴胺改性的海藻酸钠和3-氨基苯硼酸改性的羧甲基纤维素钠按照定的配比交联而成。改性后的海藻酸钠和羧甲基纤维素纳分别具有了邻苯 |
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本发明公开了种pH敏感自修复水凝胶及其制备方法。所述水凝胶由多巴胺改性的海藻酸钠和3-氨基苯硼酸改性的羧甲基纤维素钠按照定的配比交联而成。改性后的海藻酸钠和羧甲基纤维素纳分别具有了邻苯</description><language>chi ; eng</language><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G ; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS ; DERIVATIVES THEREOF ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; GENERAL PROCESSES OF COMPOUNDING ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; ORGANIC MACROMOLECULAR COMPOUNDS ; POLYSACCHARIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR PREPARATION OR CHEMICAL WORKING-UP ; WORKING-UP</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170714&DB=EPODOC&CC=CN&NR=106947094A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170714&DB=EPODOC&CC=CN&NR=106947094A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CUI GUOLIAN</creatorcontrib><creatorcontrib>YOU WEITING</creatorcontrib><creatorcontrib>DAN WEIHUA</creatorcontrib><creatorcontrib>DAN NIANHUA</creatorcontrib><title>PH-sensitive self-repairing hydrogel and preparation method of same</title><description>The invention discloses a pH-sensitive self-repairing hydrogel and a preparation method of same. The hydrogel is produced by crosslinking dopamine-modified sodium alginate and sodium carboxymethylcellulose modified by 3-aminophenylboronic acid according to a certain ratio, wherein the modified sodium alginate and sodium carboxymethylcellulose respectively have a catechol group and a phenylboronic acid group, so that between the two groups, a pH-sensitive phenylborate bond can be formed. The phenylborate bond is fractured if pH < 7 and is recovered if pH > 7, so that the hydrogel has a pH-responded self-repairing performance. A main raw material of the hydrogel is natural polysaccharide, so that the hydrogel has excellent biocompatibility and also has pH-responding property and self-repairing performance. The hydrogel has wide applications in the fields of controllable release of drugs, tissue engineering and the like.
本发明公开了种pH敏感自修复水凝胶及其制备方法。所述水凝胶由多巴胺改性的海藻酸钠和3-氨基苯硼酸改性的羧甲基纤维素钠按照定的配比交联而成。改性后的海藻酸钠和羧甲基纤维素纳分别具有了邻苯</description><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G</subject><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>COMPOSITIONS OF MACROMOLECULAR COMPOUNDS</subject><subject>DERIVATIVES THEREOF</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>GENERAL PROCESSES OF COMPOUNDING</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>POLYSACCHARIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAO8NAtTs0rzizJLEtVKE7NSdMtSi1IzCzKzEtXyKhMKcpPT81RSMxLUSgAiRcllmTm5ynkppZk5Kco5KcpFCfmpvIwsKYl5hSn8kJpbgZFN9cQZw_d1IL8-NTigsTk1LzUknhnP0MDM0sTcwNLE0djYtQAAIGuMoM</recordid><startdate>20170714</startdate><enddate>20170714</enddate><creator>CUI GUOLIAN</creator><creator>YOU WEITING</creator><creator>DAN WEIHUA</creator><creator>DAN NIANHUA</creator><scope>EVB</scope></search><sort><creationdate>20170714</creationdate><title>PH-sensitive self-repairing hydrogel and preparation method of same</title><author>CUI GUOLIAN ; YOU WEITING ; DAN WEIHUA ; DAN NIANHUA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN106947094A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2017</creationdate><topic>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G</topic><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>COMPOSITIONS OF MACROMOLECULAR COMPOUNDS</topic><topic>DERIVATIVES THEREOF</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>GENERAL PROCESSES OF COMPOUNDING</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>POLYSACCHARIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><topic>WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>CUI GUOLIAN</creatorcontrib><creatorcontrib>YOU WEITING</creatorcontrib><creatorcontrib>DAN WEIHUA</creatorcontrib><creatorcontrib>DAN NIANHUA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CUI GUOLIAN</au><au>YOU WEITING</au><au>DAN WEIHUA</au><au>DAN NIANHUA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PH-sensitive self-repairing hydrogel and preparation method of same</title><date>2017-07-14</date><risdate>2017</risdate><abstract>The invention discloses a pH-sensitive self-repairing hydrogel and a preparation method of same. The hydrogel is produced by crosslinking dopamine-modified sodium alginate and sodium carboxymethylcellulose modified by 3-aminophenylboronic acid according to a certain ratio, wherein the modified sodium alginate and sodium carboxymethylcellulose respectively have a catechol group and a phenylboronic acid group, so that between the two groups, a pH-sensitive phenylborate bond can be formed. The phenylborate bond is fractured if pH < 7 and is recovered if pH > 7, so that the hydrogel has a pH-responded self-repairing performance. A main raw material of the hydrogel is natural polysaccharide, so that the hydrogel has excellent biocompatibility and also has pH-responding property and self-repairing performance. The hydrogel has wide applications in the fields of controllable release of drugs, tissue engineering and the like.
本发明公开了种pH敏感自修复水凝胶及其制备方法。所述水凝胶由多巴胺改性的海藻酸钠和3-氨基苯硼酸改性的羧甲基纤维素钠按照定的配比交联而成。改性后的海藻酸钠和羧甲基纤维素纳分别具有了邻苯</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS DERIVATIVES THEREOF DISINFECTION, STERILISATION, OR DEODORISATION OF AIR GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP WORKING-UP |
| title | PH-sensitive self-repairing hydrogel and preparation method of same |
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